Update:  Sept 28th, 2021.

The blog post below was written about 5 years ago.  Since then we have started selling our Citrulline Peptides which is a high quality product than L-Citrulline.   

Citrulline Peptides (454 grams | 1 lbs)

L-Citrullline is an amino acid.  Typically, L-Citrulline benefits is that users hope that it will give them a better pump.  There is some good info on L-Citrulline.  The best info comes from the Japanese company Kyowa Hakko.  Recently they have received a patent for combining L-Arginine and L-Citrulline to increase blood levels of L-arginine.


Remember I’m a supplement expert with over 15 years experience in buying and manufacturing supplements.  Anyone can recommend a supplement but isnt the next question always, “What BRAND is the best?”.  Well that is the problem.  You have sites like examine.com that tell you about the ingredients but stop there.  That is pretty much worthless because you have no clue what to BRAND to BUY after that.  So you’re left with searching forums and asking self-proclaimed experts or looking at reviews that most of the time are biased.  The real answer is to ask an expert like myself.  Asking questions on a forums only gets you amateur consumer responses which is quite frankly a ridiculous way to take a recommendation with something you’re putting into your body. But you’re in luck because I am a REAL supplement expert.  I have over 10 years dealing with FDA lawyers, manufacturing consultants, employing dietary supplement experts, knowledge of the Code of Federal Regulations 111’s for dietary supplements, and much more!  I am a qualified supplement expert manufacturer, not just a science guy.  I am the real deal when it comes to recommending quality supplements because I take it a step further and recommend a brand and give you the reason(s) why!

The following is taken from the Kyowa Hakko website. 

l-citrulline benefits

Oral Supplementation with a Combination of Kyowa Hakko’s L-Citrulline and L-Arginine Can Rapidly Increase Nitric Oxide Bioavailability

April 23, 2015 New York, NY

Study Shows Promise in Human Applications for Regulating Cardio Function*  

New York City, NY (PRWEB) April 24, 2015 – A combination of L-Citrulline and L-Arginine oral supplementation caused a more rapid increase in plasma L-Arginine levels and marked enhancement of Nitric Oxide bioavailability, including plasma cGMP (Cyclic guanosine monophosphate) concentrations, than with dosage with the single amino acids.

The study, published in Biochemical and Biophysical Research Communications, set out to determine the short-term action of oral doses of L-Citrulline and L-Arginine on nitric oxide production. Results showed that the combined supplementation was significantly more effective than single doses of arginine.1

For more information about the BBRC-published study, visithttp://www.sciencedirect.com/science/article/pii/S0006291X14018178.

  1. Masahiko Morita, Toshio Hayashi, Masayuki Ochiai, Morihiko Maeda, Tomoe Yamaguchi, Koichiro Ina, Masafumi Kuzuya, Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability, Biochemical and Biophysical Research Communications, Volume 454, Issue 1, 7 November 2014, Pages 53-57, ISSN 0006-291X,http://dx.doi.org/10.1016/j.bbrc.2014.10.029.

About Kyowa Hakko’s L-Citrulline Benefits

L-Citrulline is an amino acid that plays an important role in nitric oxide metabolism and regulation. L-Citrulline is converted to L-Arginine in the body, leading to sustained increases in both L-Arginine and nitric oxide. An ingredient with application in the areas of heart health and sports nutrition, L-Citrulline is preservative-free, allergen-free, and contains no artificial flavors or colors. It’s non-hygroscopic, highly stable, and mild taste makes it suitable for use in a variety of formulations. This pure, vegetarian ingredient is also self-affirmed GRAS. Manufactured in the U.S. using a proprietary fermentation process, L-Citrulline is an ultra-pure amino acid that carries the Kyowa Quality logo, ensuring the ingredient is backed by our commitment to the highest manufacturing standards.

This is a very good video about L-Citrulline

In conclusion L-citrulline benefits can help anyone looking for a better pump and higher performance in the gym.  But it is important that you buy quality amino acids from quality manufacturers, and not junk from China.  Therefore use the Kyowa Hakko brand and you be sure that the L-citrulline benefits that you are looking for, will happen.